In volatile trade, benchmark indices turned choppy after opening higher in early trade on Tuesday on foreign fund outflows, surging global crude oil prices and weak rupee amid negative global cues.
The 30-share index fell up to 122.72 points, or 0.32 per cent, to 38,189.80, after touching a high of 38,518.56 at the outset.
The gauge has lost 584.11 points in the previous four sessions.
Similarly, the NSE Nifty declined by 50.30 points, or 0.43 per cent, to 11,532.05.
Sectoral indices led by FMCG, metal, realty, capital goods, PSU, banking, oil and gas, auto, healthcare and infrastructure, fell up to 1.54 per cent.
Major losers were HUL, Adani Ports, Vedanta, ITC, Axis Bank, Yes Bank, Sun Pharma, Coal India, Bharti Airtel, Bajaj Auto, ICICI Bank, Asian Paints, Tata Steel, SBI, Hero Motocorp, IndusInd Bank, Kotak Bank, Maruti Suzuki, ONGC and HDFC Bank, shedding up to 2.45 per cent.
However, Infosys, TCS, NTPC, Tata Motors, PowerGrid, HDFC, M&M, RIL and Wipro, gained up to 2.34 per cent.