Stress in early life extends lifespan in worms: Study

Some stress at a young age may actually lead to a longer life, according to a study conducted in worms.

Researchers at the University of Michigan in the U.S have discovered that oxidative stress experienced early in life increases subsequent stress resistance later in life.

Oxidative stress happens when cells produce more oxidants and free radicals than they can deal with.

It is part of the ageing process, but can also arise from stressful conditions such as exercise and calorie restriction, according to the study published in the journal 'Nature'.

Examining a type of roundworm called C. elegans, the scientists found that worms that produced more oxidants during development lived longer than those that produced fewer oxidants.

Researchers have long wondered what determines variability in lifespan, said Ursula Jakob, a professor at University of Michigan.

"One part of that is genetics: If your parents are long-lived, you have a good chance for living longer as well. Environment is another part," the researchers said.

That other stochastic -- or random -- factors might be involved becomes clear in the case of C. elegans, they said.

"If lifespan was determined solely by genes and environment, we would expect that genetically identical worms grown on the same petri dish would all drop dead at about the same time.

"But this is not at all what happens. Some worms live only three days while others are still happily moving around after 20 days," Jakob said.

The researchers discovered that during development, C. elegans worms varied substantially in the amount of reactive oxygen species they produce.

Reactive oxygen species, or ROS, are oxidants that every air-breathing organism produces.

(with news agency inputs)